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By blocking NNMT activity, the compound preserves nicotinamide availability for the NAD+ salvage pathway, leading to 1.2- to 1.6-fold increases in intracellular NAD+ concentrations

This approach minimizes waste while ensuring peptide availability throughout the study without forcing concentration changes mid-protocol

*Correspondence: Linsheng Gui, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi: 10.1016/j.dld.2013.10.021 76