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Another early investigation published in the European Journal of Endocrinology documented that, unlike older GH-releasing peptides, such as GHRP-2 or GHRP-6, ipamorelins GH stimulation is highly selective and does not significantly increase cortisol or prolactin levels, suggesting a cleaner hormonal profile with fewer off-target endocrine effects compared to earlier secretagogues

[264] The rapid response underscores a bidirectional relationship for autoimmune diseases, including SLE, where the dysregulated immune system exacerbates oral inflammation and dysbiosis of the oral microbiota

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