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In murine studies, the probiotic strain Lactobacillus Rhamnosus has found to make positive changes to the GABA receptors in the brain which reduces stress hormones and leads to less depression and anxiety and was via signals from the gut to the brain via the vagus nerve

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A major challenge in these conditions, and other chronic diseases with unknown causes, is identifying the biological changes that are driving symptoms, thus enabling the identification of new treatment targets

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