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The subcellular localization of eNOS influences the degree of S-nitrosylation, with membrane-bound eNOS being more heavily nitrosylated than its cytosolic counterpart due to higher NO production at the membrane (Erwin et al., 2006)

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87 Alternatively, hyperexcitable small fiber neurons in PDPN might be more susceptible to bioenergetic failure, increasing distal nerve fiber degeneration

Rotate sites systematically and document each administration [15]

[31] [32] [33] When used as directed, at a recommended maximum daily dose for an adult of three to four grams, [26] [34] paracetamol is safe and effective in the short term, [35] with uncommon adverse effects similar to those of ibuprofen