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Certain drugs are inactivated so efficiently upon their first pass through the liver that they cannot be administered orally and must be given parenterally

For injections and ERG, animals were anesthetized with ketamine/xylazine

Neutrophil extracellular traps in Candida albicans infection

Disclosures: Jae Seung Lee: Nothing to Disclose, Sung Won Lee: Nothing to Disclose, Sang Gyune Kim: Nothing to Disclose, Yeon Seok Seo: Nothing to Disclose, Su Jong Yu: Nothing to Disclose, Hyung Joon Yim: Nothing to Disclose, Hye Won Lee: Nothing to Disclose, Mi Na Kim: Nothing to Disclose, Beom Kyung Kim: Nothing to Disclose, Jun Yong Park: Nothing to Disclose, Do Young Kim: Nothing to Disclose, Sang Hoon Ahn: Nothing to Disclose, Seung Up Kim: Nothing to Disclose 407 FUNCTIONAL ANALYSIS OF FUMARYLACETOACETATE HYDROLASE AS A HEPATOCYTE HOST FACTOR GENE REGULATING HEPATITIS B VIRUS REPLICATION AND HEPATOCARCINOGENESIS Shouichi Namikawa 1 Takuto Nosaka 1 Yosuke Murata 1 Tomoko Tanaka 1 Yu Akazawa 1 Kazuto Takahashi 1 Tatsushi Naito 1 Masahiro Ohtani 1 Yasunari Nakamoto 1 , 1 University of Fukui Background: Recent molecular biological analyses have highlighted the importance of host factors in anti-viral and/or anti-tumor effects

Using antibodies specific for phosphorylation at Ser12, it was found that TCR stimulation induces DRAK2 Ser12 autophosphorylation ( 2+ into T cells

Crucially, we integrate the parallel and essential discourse on safety, highlighting how zebrafish models, especially transgenic lines, enable the real-time visualization and mechanistic interrogation of compound-induced hepatotoxicity