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Thus, it must be liberated to couple with the dedicated transport proteins

At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range

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(12) These challenges lengthen hospital stays, increase the need for readmissions or revision procedures, and impair long-term functional outcomes