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The unique design enables proximity-induced ubiquitination and subsequent degradation of target proteins

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138 Simultaneously, SIRT3 can not only induce the expression of antioxidant enzymes by activating the FOXO3a, but also enhance the activation of SOD2 and catalase via NAD + -dependent deacetylation

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Accordingly, the antioxidant defense system is found to be most useful for treating various neurological disorders

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