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Johns Wort These supplements can interfere with blood clotting or interact with sedative medications

Activated M1 (or pro-inflammatory) microglia are part of an inflammatory cascade that includes upregulation of pro-inflammatory genes, release of pro-inflammatory cytokines, and generation of ROS, which may, under prolonged conditions, contribute to the neuroinflammation observed in AD brain [97]

-Kisher, H., Gould, O

doi: 10.1024/0300-9831.71.1.82

However, few studies have explored the relationship between SUMOylation of p53 and ferroptosis

Several factors, including hypoxia, overload of all-transetinal (atRAL), high intraocular pressure, aging, and iron metabolism imbalance, lead to abnormal accumulation of iron in cells and retinas by affecting the proteins involved in the iron metabolism and homeostasis (Ugarte et al., 2013