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Moreover, a randomized double-blind placebo-controlled clinical trial indicated that supplementation with Coenzyme Q10 (30 mg/day) and L-carnitine (500 mg/day) for 8 weeks had beneficial effects on migraine symptoms and serum levels of lactate (166)

Many patients experience moderate to severe pain, often described as stabbing or burning, which can persist for years after treatment cessation, significantly impairing their quality of life (Michalova et al., 2023

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Suppression of ODC1 activity appears to redirect ornithine metabolism toward urea production rather than putrescine, and because urea can be efficiently eliminated from astrocytes via the bloodstream and excreted in urine, no adverse effects were observed under the reported treatment regimen

173 Benha University

Cabanillas ME, Zafereo ME , Williams MD, Ferrarotto R, Dadu R, Gross N, Gunn GB, Skinner H, Cote G, Grosu HB, Iyer P, Busaidy NL