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Anemia develops from B12 deficiency, as the vitamin is engaged in the production of healthy red blood cells

Furthermore, DNases I and PAD4 inhibitors, which are key players in inhibiting NETs, have exhibited anti-inflammatory effects in conditions such as NETs-related kidney injury and acute respiratory distress syndrome (140, 141)

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Oral supplementation of precursors has been shown to increase blood levels of NAD+ and this is thought to confirm the increased production of NAD+ in the cells

A serum B 12 concentration below 148 pmol/L (depending on the assay) with symptoms (box 1) is a strong indication of deficiency and is sufficient to start treatment

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