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It works over a wide pH range and is used between 0.5-1.2%

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Because Vitamin B12 and Folate are entirely co-dependent in this process, a deficiency or dysfunction in either one brings the entire methylation cycle to a grinding halt

History Scientific interest in NNMT increased substantially during the early 2000s as researchers discovered its involvement in metabolic regulation, cellular methylation processes, and adipose tissue function

10.1038/373702a0 [DOI] [PubMed] [Google Scholar] Ueki R., Uchida S., Kanda N., Yamada N., Ueki A., Akiyama M., et al