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GSH reductase Loss of activity of glutathione peroxidase 4 (GPX4) in a process called ferroptosis, leads to accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides

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349 Meanwhile, RA patients typically have lower antioxidants, such as GSH and GSH peroxidase, and treatment with methotrexate significantly changes oxidative stress indicators in RA patients

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