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BOTTOM LINE: Vitamin B12 is a water-soluble vitamin that plays an important role in brain function and red blood cell production

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Because the peptide occurs naturally in human plasma (at roughly 200 ng/mL in young adults, declining to approximately 80 ng/mL by age 60), topical supplementation essentially restores youthful local concentrations in treated skin

These shifts occurred without altering BM-PB metabolic ratios, indicating preserved enzymatic balance despite systemic therapy

In ambiguous cases, methylmalonic acid or homocysteine can help