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Aksoy S, Szumlanski CL, Weinshilboum RM

Of those, 35 were preclinical and only one involved humans [8]

Second, B12 undergoes enterohepatic recirculation cobalamin secreted in bile is reabsorbed in the ileum through the same intrinsic-factor pathway so a genetic weakness in absorption is amplified over time by loss of the recycled pool

Genetic determinants of serum vitamin B12 and their relation to body mass index We found no support for a causal role of decreased serum vitamin B12 levels in obesity