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Further validation into higher order in vivo experimental models is imperative in order to explore the potentials of antioxidant nanoparticles

In addition, haem oxygenase 1 (HMOX1) is upregulated in embryonic ferroptosis, and inhibition of HMOX1 can maintain normal mitochondrial function, thereby preventing ferroptosis from occurring [16]

doi:10.1073/pnas.71.10.3879

Notably, the observed downregulation of Metallothionein-2 (Mt2) in the serum proteome results, a well-established inducible antioxidant and metal-chelating protein in serum, strongly supports the interpretation of reduced oxidative stress