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Helps protect cells from everyday environmental stressors

Furthermore, the activation of Notch signaling has been observed in I/R-induced AKI models, subsequently triggering the activation of p21 and p16 INK4a and intensifying interstitial fibrosis development [65]

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NR, however, bypasses extracellular degradation allowing for more stable and prolonged elevation of NAD+ within cells

Notably, we found that Sox2-positive NSCs did not always express neogenin (Supplementary Fig