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Significantly, a novel rapid arousal intranasal delivery system (RA-IDDS) was developed to ensure targeted delivery of NanoCA to the brain, which provided substantial neuroprotection to alleviate behavioral deficits and enhance the clearance of monomers, oligomers and aggregates of -syn in the midbrain (Liu et al., 2020)

Collectively, These results suggest a central position of NNMT in the development of MetS

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However, DCI has also been found to inhibit aromatase (the enzyme that promotes conversion of androgens to estrogens in the ovaries), and higher doses have been found to increase circulating testosterone levels in women with PCOS