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Voclosporin, a novel calcineurin inhibitor, was investigated in a phase II trial for lupus nephritis as a combination therapy with mycophenolate mofetil (AURA trial)

Chronic inflammation from misuse can trigger post-inflammatory hyperpigmentation on darker skin tones

It sits well under the ~500 Da Lipinski cutoff for good oral absorption, so absorption is built into the chemistry

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Silymarin downregulates MPO/MDA [534] and blocks the IL-6/STAT3 [535]-cell division cycle 25C (Cdc25C)/(cyclin-dependent kinase 1) CDK1 [536] proliferation signal