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In mouse layer V extratelencephalic-projecting neurons, HTR1A and HTR1F were the dominantly expressed subunits, whereas, in human layer V extratelencephalic-projecting neurons, HTR1E (which is absent in the mouse genome) and HTR1F were highly expressed, with little HTR1A expression

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Psychotropic drugs with active metabolites include anxiolytics such as diazepam and clobazam, antidepressants such as fluoxetine and venlafaxine, and antipsychotics such as risperidone and cariprazine