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The epigenetic mechanisms include methylation and/or demethylation of DNA, post-translational modifications of histones, and non-coding RNAs such as microRNAs (Casanello et al., 2018)

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Increased HGF expression has been correlated to anoikis resistance by fibronectin signaling in HNSCC by disrupting the integrin signaling [90]

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Also, a similar protocol was successful in the therapy of the other fistulas, that is, gastrocutaneous (Skorjanec et al., 2009), esophagocutaneous (Cesarec et al., 2013), duodenocutaneous (Skorjanec et al., 2015), vesicovaginal (Grgic et al., 2016), and rectovaginal (Baric et al., 2016) in rats

Therefore, suspicion for these entities is an indication for the diagnostic use of cystoscopy