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Finally, as both EZH2 and CDK5 have independently been shown to be critical for NEPC progression, it is likely that they reside in different compartments where each promotes specific oncogenic pathways

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Noradrenergic regulation of inflammatory gene expression in brain

[70] demonstrated that the phosphorylated STAT3 proteins interacted with the phosphorylated FoxO1 and FoxO3a proteins in the cytoplasm of mouse CD4 + T cells and subsequently promoted the import of the complex into nuclei where the dephosphorylated FoxO proteins transactivated specific genes

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Additionally, PFK15 treatment decreased glucose (2-NBDG) uptake by CD4 + T cells upon stimulation to levels similar to T cells in media alone ( Figures 1C, D )