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TLR2-Deficiency Promotes Prenatal LPS Exposure-Induced Offspring Hyperlipidemia

Compared to AZEpaclitaxome-2 that has ~5 molar% DSPE-PEG 2K , this CD47p coating strategy significantly prolonged circulation time (by 1.67-fold) and delivered more drug to tumors (by 2.40-fold), while reducing the distribution to liver, spleen, lung and kidneys due to the MPS avoidance (Fig

It can inhibit the expression of CD36 and phosphorylated phospholipase C (p-PLC), improve abnormal lipid metabolism in T2DM mice, reduce excessive free fatty acid (FFA) uptake by renal cells, and exert anti-inflammatory and antifibrotic effects [143]