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Although direct interaction between 4-HNE and caspase-3 in psoriatic tissue is not fully confirmed, elevated caspase-3 activity and increased 4-HNE-protein adduct formation support its pro-apoptotic role [47,48]

Rituximab The anti-CD20 monoclonal antibody rituximab is approved for the treatment of many diseases, including non-Hodgkin lymphoma (NHL), chronic lymphocytic leukaemia (CLL) and rheumatoid arthritis [31]

BPC-157 for arthritis applications focus on slowing progression rather than reversing disease

While this creates therapeutic vulnerabilities, conventional metabolic inhibitors face critical limitations in systemic toxicity, metabolic heterogeneity, and inadequate tumor accumulation

For the metabolomics of cell cultures, cells were differentiated in 6-well plates

Cells were fixed, permeabilized, and incubated with the primary antibodies followed by fluorophore-conjugated secondary antibodies