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The mammalian target of rapamycin (mTOR) signaling pathway is a sensor of cellular stress and growth factor signals that regulates cell growth 35 and inhibit autophagy 36,37

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Here we report cryo-EM structures of RyR1 in the absence and presence of atorvastatin, firmly establishing RyR1 as an unintended off-target

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Tofacitinib ameliorates murine lupus and its associated vascular dysfunction