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Persistent bilateral ureteral obstruction secondary to endometriosis despite treatment with an aromatase inhibitor

Loss of proteostasis Proteostasis refers to the dynamic balance of a complex network of proteins in cells, including protein synthesis, structural and functional maturation, protein quality control, folding modification, localization and transport, functional recovery and degradation

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But the primary concern is the risk of ochronosis, a rare but challenging condition where long-term overuse paradoxically causes darkening of the skin, says Francesa Lewis, MD, a board-certified dermatologist in Delray Beach, Florida

When acne is very severe and scar formation is impending, photodynamic therapy or systemic treatments are indicated