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Alterations in glycolysis, glutaminolysis, or serine/glycine metabolism in cancer cells promote survival as a result of increased levels of GSH, which allow tumor cells to withstand their enhanced oxidative environment ( 5 , 9 11 ), and the pentose phosphate pathway, an offshoot of glycolysis, provides NADPH [reduced form of nicotinamide adenine dinucleotide phosphate (NADP + )]reducing equivalents to maintain GSH homeostasis ( 12 )

Pyridoxal phosphate (PLP) is integral to one-carbon metabolism, a series of biochemical reactions necessary for the synthesis of nucleotides and other molecules essential for DNA and RNA production (57, 58)

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Formula T(1/2) = (0.69 x Vd)/CL From this equation, we see that the key determinants of half-life are the Volume of Distribution and the Clearance, which we now can calculate, if we have the necessary values

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The aberrant NF-B signaling and expression of BARTs form an autoregulatory loop for maintaining EBV latency in NPC cells