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Together with local infiltration and activation of circulating immune cells, these processes may contribute to the pathogenesis of vascular inflammatory disorders which have been linked to the onset and/or progression of several neuroinflammatory and neurovascular diseases [70, 71]

In other words, there should be a detectable signal in population prevalence trends: either a slowing down of the decline in smoking (beyond the natural flattening of the curve as smoking prevalence declines exponentially to its natural floor) or an increase in smoking (especially if the gateway effect is large)

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According to them nowadays the Cyprian latakia is produced in the Izmir region of Turkey