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For example, SLC39A8 co-transports Zn and Mn, and its loss of function concurrently reduces renal levels of both metals, highlighting its intricate role in maintaining metal homeostasis 117

However, when the acute inflammatory response is self-limited through NETs and AGGNets, residual immune stimulation can cause inflammation to transition from a reversible acute phase to a chronic remodeling phase if the crystals are not completely removed (137)

Real world evidence will be critical in determining durability of effect, adherence, and tolerability across diverse patient populations

The number of cell colonies (normoxic: 159 clones, hypoxia: 106 clones) was the lowest in the Bi 2 S 3 -3BP + X-ray treated group under both normoxic and hypoxia conditions (Fig

Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors

Sci Transl Med 7 , 274ra217, (2015)