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Free acids are the preferred substrates for 9-LOX, and under conditions of stress in plants, lipases or unspecific acyl-lipid hydrolases are activated that rapidly break down the complex lipids, another analogy with animal systems, and initiate oxylipin synthesis, but it is evident that 13-LOX can react with esterified fatty acids in lipids also and perhaps disrupt the cellular membranes as in stress situations

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