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WNK1OSR1 kinase-mediated phospho-activation of Na + K + 2Cl cotransporter facilitates glioma migration

Good Old Fisticuffs: Has a shield and a sword, but prefers the use of his fists

Concurrently, activation of the IRE1-JNK pathway phosphorylates the pro-apoptotic protein Bim and inhibits the anti-apoptotic function of Bcl-2, ultimately activating Caspase-3 to execute the cell death program [356]