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OA is characterized by progressive loss of cartilage extracellular matrix (ECM) and pathological changes in other joint tissues such as subchondral bone sclerosis, osteophyte formation, and synovial inflammation 31

In response to these dangerous cytokines, the Nuclear erythroid-2-related factor-2 (Nrf2) pathway is turned on [12]

S18B), but it strongly abrogated BSO-induced accumulation of cellular lipid peroxides and mitochondrial ROS and lipid peroxides (Fig

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Yuan Q, Wang Y, Song R, Hou X, Yu K, Zheng J, et al

(1995) The content of glutathione and glutathione S-transferases and the glutathione peroxidase activity in rat liver nuclei determined by a non-aqueous technique of cell fractionation