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However, cancer cells have developed various mechanisms for T cell depletion, which is an adverse factor in HCC, circumventing immune monitoring, such as promoting T cell fatigue blocking T cell penetration, and inducing immunosuppressive factors [86]

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discovered that oestrogen-activated GPER in CAFs promotes the expression of GLUL and lactate dehydrogenase B (LDHB), enhances the survival of Triple Negative Breast Cancer(TNBC) cells both in vitro and ex vivo, and increases chemotherapy resistance [130]

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While generally safe, some individuals may experience mild side effects such as gastrointestinal discomfort or allergic reactions

Cabozantinib might prove to be a game changer in the treatment approach and the natural history of CCS