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Impaired mitochondrial function in brain cells reduces plasticity, impairing synaptic functioning and decreasing cellular resilience.[ref] Is elevated cortisol the only way to cause mitochondrial dysfunction

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Mario G Ferruzzi, Jirayu Tanprasertsuk, Penny Kris-Etherton, Connie M Weaver, Elizabeth J Johnson, Perspective: The Role of Beverages as a Source of Nutrients and Phytonutrients, Advances in Nutrition, , nmz115, Bente L Halvorsen, Monica H Carlsen, Katherine M Phillips, Siv K Bhn, Kari Holte, David R Jacobs, Rune Blomhoff, Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States, The American Journal of Clinical Nutrition, Volume 84, Issue 1, July 2006, Pages 95135, Echeverri D, Montes FR, Cabrera M, Galn A, Prieto A

There is research that the human syndrome is a neurodegenerative disorder resulting from Tau-mediated excitotoxic neurodegeneration