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The data suggests that the purified antibodies from the lupus patients are polyclonal and that the B-CLL and normal donor antibodies were monoclonal, thus accounting for the different banding patterns

Consistent with its proposed, exclusive role in the maturation of [4Fe-4S] clusters, ABCB7 deletion has little effect on mitochondrial [2Fe-2S] + protein activity but results in functionally deficient cytosolic and nuclear [4Fe-4S] 2+ proteins ( + cluster ([2Fe-2S](SG) 4 ) is the natural substrate for ABCB7, and is thus, represents the [2Fe-2S] + cluster that is utilized by the CIA machinery ( 2+ cluster formation to occur