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Werner syndrome (WS), which is distinguished by severe metabolic dysfunction, dyslipidemia, early atherosclerosis, and insulin resistance diabetes, is thought to most closely mimic normal aging

Measurement of single-myocyte excitability, contractility, and Ca 2+ transients Myocytes were enzymatically isolated as described previously ( 2+ transients (loaded with FURA-2AM)

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The same trend was measured for the Albu-LiTE constructs, despite that more of the constructs were detected in the medium, possibly due to anti-EGFR nanobody in the LiTE construct binding to EGFR on the cell surface of the HMEC-1 cells (Supplementary Fig