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J Nutr Biochem (2014) 25(5):50314.10.1016/j.jnutbio.2013.10.012 68 SokolovAVAgeevaKVPulinaMOZakharovaETVasilyevVB

From 44 antioxidant-related genes, 16 (including GPX2, GPX3, GCLM, GCLC, and TXNRD1) showed a significant upregulation in the airway epithelium of smokers in comparison with nonsmokers (18)

In the topiramate group, 2 patients experienced mild adverse effects, which were drowsiness and dizziness

Bioinformatic analysis may be a future direction, but the validity and clinical significance of the molecules identified with this approach need to be further explored