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Collectively, our findings suggest that microplastic pollution may represent an emerging environmental risk factor for the development and progression of kidney stones, while also providing new mechanistic rationale and perspectives for targeting LRP6 as a potential therapeutic strategy

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At all time points tested, P-Mn/TI@mHSA exhibited a relatively higher fluorescence signal in the aortic tree compared to Mn/TI@mHSA, suggesting improved delivery to the plaque regions facilitated by platelet carriers

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For example, the bone marrow mesenchymal stem cell (BMSC)-derived lncRNA Mir9-3hg was reported to inhibit ferroptosis via regulating the pumilio RNA binding family member 2 (Pum2)/peroxiredoxin 6 (PRDX6) axis [155]

AMD-Driving Pathogenic Pathways Despite extensive research, we still do not fully understand critical drivers involved in the initiation of AMD and progression from the early to advanced stages