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Electrochemotherapy (ECT) synergistically combines PEFs with chemotherapeutic agents: drugs are administered intratumorally before PEFs application, where transient membrane permeabilization enhances intracellular drug uptake, significantly potentiating cytotoxicity against treatment-resistant malignancies

In humans, the BDNF gene is located on chromosome 11p14.1 consisting of 11 exons (IXI) and nine promotors that regulate the developmental and regional expression of multiple alternatively spliced mRNA isoforms (Pruunsild et al

184 NAD + manipulates the gene expression Cellular metabolism, such as NAD + metabolism, is directly connected to gene expression through regulating the post-translational modifications (PTMs) of histones, the covalent chemical modifications of DNA, the activity of transcription factor and RNA processing

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Shuying (Sheri) Yang is an associate professor in the Department of Basic & Translational Sciences in the University of Pennsylvania School of Dental Medicine

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