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To partially compensate for this, patients are often given high systemic doses, which may increase brain exposure but also lead to significant off-target toxicity

Ninety-six-well MaxiSorp Immuno ELISA plates (ThermoFisher, Waltham, MA, USA) were coated with 200 ng/well hACE-2-Fc (CIM, Cuba) in 0.1 M carbonate-bicarbonate buffer (pH 9.6) and incubated overnight at 4C

Interestingly, glutamate levels were the same between the patients and the control group.[ref] Epilepsy: Too much excitation in neurons in certain regions of the brain can cause epilepsy or spastic disorders

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For instance, MSNs that confine two different enzymes or enzyme mimics within the pore channel can be used as a nanoreactor for biomimetic cascade catalysis