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By the middle of the twentieth century, enzymatic systems able to catalyse NADPH-dependent reduction of glutathione had also been detected in plant tissues (Conn and Vennesland 1951

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For example, antioxidant gene therapy has been suggested as a means of overcoming the problem of poor delivery and bioavailability of antioxidant compounds at their intended sites of action (Firuzi et al., 2011)