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Linker selection requires comprehensive consideration of payload characteristics, target tissue microenvironment, pharmacokinetics, and clinical requirements

10.1016/j.ejmech.2021.113419 Eur J Med Chem

Evading apoptosis is one of the hallmarks of cancer cells

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the cytotoxic drugs can comprise intracellularly acting cytotoxic drugs that are, e.g., small organic molecules, cytotoxic proteins or peptides, radiation emitters, including, for example, short- range, high-energy a-emitters as described above, and the like