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Description

van Baak, M

Reynolds J

The inhibition of SGLT2 decreases the expression of HIF-1 in human proximal tubules under hypoxic conditions, leading to a reduction in tubular damage and interstitial fibrosis (274, 275)

Importantly, continuous subcutaneous infusion of LPS showed a tendency to cause the change of glucose metabolism and the pattern of weight gain was similar to that seen when taking a high-fat diet [189, 190]

It has been found that microbial metabolites from the gut are not only regulators of inflammation but also the initial instructions for reprogramming the energy metabolic pathways of lung immune cells (such as macrophages and neutrophils)