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beyond the plasma membrane (FSP1) and mitochondria (DHODH), the specific antioxidant mechanisms in organelles such as the endoplasmic reticulum (a major site of lipid synthesis) and peroxisomes (involved in lipid oxidation) are poorly defined, and their crosstalk with cytoplasmic SOD/CAT remains elusive

Recently, Guan et al found that patients with severe AH exhibited significantly higher IL-8-positive neutrophils in the liver compared with patients with alcohol-associated liver cirrhosis, contributing to persistent inflammation

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Nevertheless, vitamin K supplements was found to remarkably decrease the probability of hip fractures in individuals older than 75 years old [85]