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A 90-person Indonesian multicentre trial testing oral glutathione plus vitamin C, alpha-lipoic acid, and zinc over 12 weeks in participants with Fitzpatrick IV and V skin types, a melanin range broadly similar to a lot of Indian skin found the glutathione group trended better on spot and tone measurements, but the difference from placebo didn't reach statistical significance for the group as a whole

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It achieves this by preventing the production of melanin, which is the chemical causing spots and an irregular tone of the skin