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Other symptoms may include catching, locking or giving out of the knee

Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research

If it freezes (below 0 degrees), ice crystals can damage the peptide structure

Physical property changes Lyophilized powder appearance changes indicate moisture absorption or other degradation

However, intranasal administration is also considered an efficient route for systemic effects due to the dense vasculature of the nasal mucosa

Injection Technique General subcutaneous guidance from clinical bestpractice resources [7] [8] [9]