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A study in hairless guinea pigs (the most appropriate alternative to the human skin in in vitro studies due to similar cannabinoids permeability results) has demonstrated that, by using Transcutol as a penetration enhancer at 6% (v/v) in a CBD transdermal gel formulation, pharmacokinetic parameters had a noteworthy improvement and an enhancement factor of 3.7

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Botox earned its benchmark status the hard way through decades of clinical use and the largest body of research of any neurotoxin

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doi: 10.1016/s0006-3223(02)01811-5