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Mechanistically, it binds the IGF-1 receptor (IGF-1R)

Genetic factors to consider include: Mutations in the MTHFR gene, which can affect folate and B12 metabolism Variations in genes involved in B12 transport and utilization Understanding these factors helps doctors give better care

After the groups comparison (group1 = poor outcome, group2 = favourable outcome for mRS 0-2) we adjusted for possible confounders the association of the investigated biomarkers with poor outcome in a logistic regression

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and Kanzaki, M

Cyclin D1 overexpression in thyroid papillary microcarcinoma: its association with tumour size and aberrant catenin expression