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DALY rates increased from 2.32 (95% UI, 0.30 to 5.95) per 100,000 in 1990 to 2.70 (95% UI, 0.36 to 6.83) per 100,000 in 2021, an increase of 16.26% (95% UI, 8.0427.07), with an EAPC of 0.50 (95% CI, 0.390.62)

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This heightened oxidative burden extends beyond immune cells to the airway epithelial cells, which are primary sites of CFTR dysfunction (Regelmann et al., 1991)

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The key histological abnormalities of AD include necrosis and apoptosis of VSMCs, fracture of elastic fibers, and degradation of extracellular matrix (ECM) (73).The thrombi formed within the false lumen indicates the presence of continued inflammation under the condition of atherosclerosis and chronic inflammation, and the higher risk of rupture in patients with inflammatory diseases demonstrates the importance of inflammation in AD (74)