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Materials and methods Mice All animal studies were performed in compliance with the animal policies of the Max Planck Institute of Experimental Medicine, and were approved by the German Federal State of Lower Saxony

A more prudent and balanced approach to fortification with folic acid, or preferably a natural reduced folate, combined with vitamin B12 would potentially improve the benefits and reduce the harms, including epigenetic and transgenerational risks, associated with current public health policies

aureus (JE2-lux) cultures were incubated with 10 or 40 M KL1 for 4 h, followed by luminescence detection

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Even using this strategy some patients (minority) do have issues with sleep for the first 1-2 days after each injection