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Change in knee contact force with simulated change in body weight

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Even though there have been several studies, the underlying molecular mechanisms of the action of green tea polyphenols in BM loss and reducing the metabolic syndrome are still unclear (Reference Yang, Zhang and Zhang114)

Andrologia 52 (9), e13674 (2020)

This effect was attributed to TFPs high viscosity and uronic acid content (26.7%), as uronic acids like galacturonic and glucuronic acids can bind cholesterol, potentially reducing lipid accumulation (70)

Consequently, an extracellular cystine or intracellular cysteine deficiency or inhibition of system ( SLC7A11 ) would reduce the GSH level, inhibit GSH-dependent GPX4 activity, and lead to the intracellular accumulation of L-ROS and cell death (Dolma et al., 2016